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KMID : 0900920000240030241
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Korean journal of Animal Reproduction
2000 Volume.24 No. 3 p.241 ~ p.248
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Effects of a Herb Drug Extracts on Mitigation of Reproductive Toxicity after a Continuous Dose of Dioxin in Mice
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Kim Sang-Keun
Kim Min-Soo
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Abstract
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In this study, we examined the number and motility of sperms, and also observed the changes in testes weight, and histological changes of several organs after 5 days of a continuous administration of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) of per oral administration of a herb drug extracts, which were administerated altermate days, to elucidate the effects of the a herb drug extracts on reproductive toxicity of dioxin. 1. The sperm numbers of dioxin-administered groups were 90.7pm3.6~l18.5pm3.6times10/suup 6/mell and 67.3pm4.1~88.2pm3.3times10^{6} mell for 10~20 mutextrm{g}/kg and 30~40 mutextrm{g}/kg dosages of dioxin-administerated groups, respectively. Each dioxin-administered group showed prominently lower value than that of control group’s which was 119.3pm3.4~120.2pm4.7 times 10^{6.}mell. 2. The sperm motility of each dioxin-administered group’s also showed lower value than that of control group’s which was 93.6pm3.8~94.9pm3.4%. The sperm motility of each dioxin-administerated group were 77.0pm4.7~89.5pm3.6% and 66.5pm3.3 ~79.9pm3.8% for 10~20 mutextrm{g}/kg and 30~40 mutextrm{g}/kg dosages of dioxin-administerated groups, respectively. 3. The sperm numbers of each group, which was administered a herb drug extracts, were 77.4pm3.2~90.9pm3.4times10^{6} mell, 78.0pm3.3~105.0pm4.2times10^{6} mell, 76.2pm2.8~84.4pm3.5times10^{6} mell and 75.4pm3.3~80.2pm3.3times10^{6} mell for extracts of green leaf, red ginseng, Kugija and Oume-administered groups respectively. And the sperm motility of each group were 63.4pm3.8~77.0pm4.0%, 65.5pm4.1~87.4pm3.8%, 64.3pm4.2~69.8pm4.2%, 66.3pm3.9~66.0pm0.40% for extracts of green leaf, red ginseng, Kugija and Oume extracts-administered groups, respectively. 4. The number and motility of sperm of control group were 119.3pm3.4~120.2pm4.7times10^{6} mell and 93.0pm3.5~96.1pm3.5%, respectively. Red ginseng extracts- administered group seemed to be recovered than my other groups, and the green leaf extracts-administered group was shown to be the next. The Kugija and Oume extracts-administered groups didn’t show to be recovered much. 5. Most a herb drug extracts-administered group except the red ginseng-administered group displayed prominently lower values of testes weights than that of control group’s which was 0.15pm0.01~0.16pm0.01g. The red ginseng extracts-administered group seemed to be recovered conspicuously. 6. After 5 days of a continuous administration of 30 mutextrm{g}/kg dosage of dioxin followed by 3 weeks of per oral administration of green leaf, red ginseng, Kugija, or Oume extracts, histological findings showed that the liver, spleen, and testis of most a herb drug extracts-administered groups were damaged severely. By the way, the testes of red ginseng extracts-administered group seemed to recover compared to the other group’s.ompared to the other group’s.
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KEYWORD
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Dioxin, Reproductive toxin, No. of sperm, Sperm motility
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